Even at a relatively high dose of fluoxetine, she continued to experience significant anxiety.Fluoxetine is ‘activating’ in some people, meaning that it sometimes increases the person’s sense of energy, which can, in turn, increase anxiety.Fluoxetine is indicated for premenstrual dysphoric disorder or ‘PMDD’, but I think most psychiatrists would say that any SSRI would work in a similar fashion for that condition. From what I can see, they reduce negative obsessing, negative rumination, obsessing over worry about perceptions by others… I do not generally see a ‘lift’ in mood, as much as a letting go of negative thoughts, negative self-reflection, and worry.Lexapro is a very potent SSRI; the most potent of all of the SSRIs.At some point we decided to change to escitalopram, brand name Lexapro, a newer SSRI that has a high potency and somewhat less activation.After two months, the anxiety seemed to be a little worse if anything; certainly not improved.
Pros: An SNRI that’s generally well tolerated if started in low doses.
depression, in consideration of changing back to fluoxetine, or to a different medication altogether.
My Response: Hi XXXXXXX, Lexapro and fluoxetine are both SSRIs, i.e. The same can be said for citalopram (which is virtually identical to Lexapro, generic name escitalopram), sertraline (Zoloft), and paroxetine (Paxil).
Some of these extra actions are useful some are not.
For example, fluoxetine tends to reduce appetite and boost energy in MOST, but not all people— effects that some people find desirable.
The individual differences between medications probably have more to do with misperception and placebo effects than true differences between the medications, with a few exceptions.